In this module, we outline the approach to a patient who may have hypercalcemia. From a thorough description of possible causes, to a helpful memory aide for clinical presentations, you will glean an understanding of hypercalcemia. Important questions to ask in a history including onset, timing and associated symptoms are discussed. With presentations that range from incidental lab finding, to overt cardiac disease, we emphasize that it is important to avoid the “gunshot” approach in the work up of these patients. Rather use clinical impression to direct investigations and imaging modalities. Management varies based on etiology, however general principles of management are described.